503A · CompoundedIllustration only. Actual medication will vary.Women's Health · Menopause & hormones
Bi-Est +
Progesterone Cream
A compounded hormone cream combining biestrogen (estriol and estradiol, 50/50) with progesterone. Two strengths, in a 30 g tube.
Your Plan Options
Bi-Est 0.1% / Progesterone 4%
30 g tube · 30-day supply
$139 /mo
Bi-Est 0.1% / Progesterone 4%
30 g tube · 90-day supply
$379 /3 mo
Best value
Bi-Est 0.2% / Progesterone 10%
30 g tube · 30-day supply
$139 /mo
Bi-Est 0.2% / Progesterone 10%
30 g tube · 90-day supply
$379 /3 mo
Best value
No charge until a provider prescribes. Prescription required.
Clinical information
What this is, in plain language.
Biestrogen is a blend of estriol and estradiol. This cream combines it with progesterone for topical application. It is prepared by a licensed 503A compounding pharmacy and dispensed only when a licensed provider determines it is clinically appropriate, with follow-up visits every 3 months.
Active ingredients
Biestrogen (50/50 estriol/estradiol) 0.1% or 0.2%, with progesterone 4% or 10%.
Mechanism
Supplements estrogen and progesterone levels that decline around menopause.
Administration
Applied to the skin daily, as directed by your prescriber.
Who it is for
Adults experiencing perimenopause or menopause symptoms, when clinically appropriate.
Common effects
Breast tenderness, spotting, bloating, headache. Discuss full risks, including blood clots and stroke, with your provider.
Important safety & compliance information
Compounded biestrogen / progesterone cream is not FDA-approved. It is prepared by a licensed 503A compounding pharmacy and is descriptive only — it is not a branded drug. Product imagery shown here is illustration only; actual medication is dispensed in a pharmacy-labeled container and will vary in appearance. A prescription is required and is issued only when a licensed provider determines treatment is clinically appropriate. This page is not medical advice. Discuss benefits, risks and side effects with your provider.